4-Nitrobenzenesulfonyl chloride
- CAS NO.：98-74-8
- Empirical Formula: C6H4ClNO4S
- Molecular Weight: 221.62
- MDL number: MFCD00007445
- EINECS: 202-697-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:13
What is 4-Nitrobenzenesulfonyl chloride?
Chemical properties
yellow to brown powder, soluble in toluene,tetrahydrofuran,methylene chloride and ethyl acetate. Insoluble in water.
The Uses of 4-Nitrobenzenesulfonyl chloride
4-Nitrobenzenesulfonyl Chloride is used in the preparation of N-Nosyl-α-amino acid for peptide synthesis.
The Uses of 4-Nitrobenzenesulfonyl chloride
4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (bipy = 2,2'-bipyridine, nbs = 4-nitrobenzenesulfonate).
Production Methods
4,4'-Dinitrodiphenyldisulfide [100-32-3], produced by reaction of 4-chloronitrobenzene with sodium disulfide, is treated with chlorine in HCl – HNO3 by a process similar to that used for 2-nitrobenzenesulfonyl chloride.
Flammability and Explosibility
Not classified
Properties of 4-Nitrobenzenesulfonyl chloride
| Melting point: | 75 °C |
| Boiling point: | 143-144 °C (1.5002 mmHg) |
| Density | 1.602 (estimate) |
| vapor pressure | 0.009Pa at 20℃ |
| refractive index | 1.6000 (estimate) |
| Flash point: | 143-144°C/1.5mm |
| storage temp. | Store below +30°C. |
| solubility | soluble in Toluene |
| form | Powder |
| color | yellow |
| PH | 1 (H2O, 20℃) |
| Water Solubility | Insoluble |
| Sensitive | Moisture Sensitive |
| BRN | 746543 |
| Stability: | Moisture Sensitive |
| CAS DataBase Reference | 98-74-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Nitrobenzenesulphonyl chloride(98-74-8) |
| EPA Substance Registry System | Benzenesulfonyl chloride, 4-nitro- (98-74-8) |
Safety information for 4-Nitrobenzenesulfonyl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for 4-Nitrobenzenesulfonyl chloride
4-Nitrobenzenesulfonyl chloride manufacturer
JSK Chemicals
ASM Organics
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