Ethanesulfonyl chloride
- CAS NO.：594-44-5
- Empirical Formula: C2H5ClO2S
- Molecular Weight: 128.58
- MDL number: MFCD00007460
- EINECS: 209-842-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-13 11:09:07
What is Ethanesulfonyl chloride?
Chemical properties
clear light brownish to pinkish-purple liquid
The Uses of Ethanesulfonyl chloride
Chloroethylsulfone was used in discovery of a selective inhibitor of oncogenic B-raf kinase with potent antimelanoma activity.
What are the applications of Application
Ethanesulfonyl chloride can make sulfonyl-substituted imides, methide lithium salts, and pentafluoroethanesulfonyl fluoride, a fluorinated surfactant. It is an intermediate in synthesizing new, low-cost, non-fluorinated, sulfonyl-substituted imide and methide lithium salts and an intermediate in preparing the fluorinated surfactant pentafluoroethanesulfonyl fluoride.
Synthesis Reference(s)
Journal of the American Chemical Society, 61, p. 2548, 1939 DOI: 10.1021/ja01878a085
Properties of Ethanesulfonyl chloride
| Melting point: | -70°C |
| Boiling point: | 177 °C (lit.) |
| Density | 1.357 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 182 °F |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | soluble in dichloromethane,Ether |
| form | Liquid |
| color | Clear colorless to light yellow or light brownish to pinkish-purple |
| Water Solubility | DECOMPOSES |
| Sensitive | Moisture Sensitive |
| BRN | 773865 |
| CAS DataBase Reference | 594-44-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanesulfonyl chloride(594-44-5) |
| EPA Substance Registry System | Ethanesulfonyl chloride (594-44-5) |
Safety information for Ethanesulfonyl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H330:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Ethanesulfonyl chloride
| InChIKey | FRYHCSODNHYDPU-UHFFFAOYSA-N |
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