5-Chlorosalicylaldehyde
- CAS NO.：635-93-8
- Empirical Formula: C7H5ClO2
- Molecular Weight: 156.57
- MDL number: MFCD00003331
- EINECS: 211-244-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is 5-Chlorosalicylaldehyde?
Chemical properties
white to very slightly yellow crystalline powder
The Uses of 5-Chlorosalicylaldehyde
5-Chlorosalicyaldehyde is a useful synthetic intermediate and a key precursor to a variety chelating agents.5-Chlorosalicyaldehyde is used to synthesize imine resveratrol (R150000) derivatives as multi-targeted agents against Alzheimer's disease.
Synthesis Reference(s)
Synthetic Communications, 20, p. 609, 1990 DOI: 10.1080/00397919008244911
Tetrahedron Letters, 15, p. 3463, 1974
Purification Methods
Steam distil it, then crystallise it from aqueous EtOH or *C6H6 (m 100o). It forms complexes with Cu2+ and Fe2+ . [Beilstein 8 H 53, 8 II 45, 8 III 181, 8 IV 224.]
Properties of 5-Chlorosalicylaldehyde
| Melting point: | 100-102 °C(lit.) |
| Boiling point: | 217.69°C (rough estimate) |
| Density | 1.2683 (rough estimate) |
| refractive index | 1.5812 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Crystalline Powder |
| pka | 7.73±0.18(Predicted) |
| color | White to very slightly yellow |
| Sensitive | Air Sensitive |
| BRN | 636632 |
| CAS DataBase Reference | 635-93-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 5-Chloro-2-hydroxy benzaldehyde(635-93-8) |
| EPA Substance Registry System | Benzaldehyde, 5-chloro-2-hydroxy- (635-93-8) |
Safety information for 5-Chlorosalicylaldehyde
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H400:Hazardous to the aquatic environment, acute hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Chlorosalicylaldehyde
5-Chlorosalicylaldehyde manufacturer
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