5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
Synonym(s):5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
- CAS NO.：118414-59-8
- Empirical Formula: C22H15Cl2NO2S
- Molecular Weight: 428.33
- MDL number: MFCD06798322
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:49:03
![5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid Structural](https://img.chemicalbook.in/CAS/GIF/118414-59-8.gif)
What is 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid?
The Uses of 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
nTZDpa is a PPARγ agonist, with pharmaceutical applications such as anti-diabetic drugs.
What are the applications of Application
nTZDpa is a non-thiazolidinedione PPARγ partial agonist
Biological Activity
Potent, selective non-thiazolidinedione PPAR γ partial agonist (EC 50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC 50 ~ 285 nM). Displays no activity at PPAR α or PPAR δ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPAR γ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo .
Storage
Store at +4°C
Properties of 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
| storage temp. | Store at +4°C |
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| color | white to beige |
Safety information for 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
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