5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
- CAS NO.：6981-18-6
- Empirical Formula: C14H18N4O2
- Molecular Weight: 274.32
- MDL number: MFCD00057747
- EINECS: 230-246-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-16 07:06:08
What is 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine?
The Uses of 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.
The Uses of 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.This compound is a contaminant of emerging concern (CECs).
Definition
ChEBI: 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine is a dimethoxybenzene.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 14, p. 462, 1971 DOI: 10.1021/jm00287a029
Properties of 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
| Melting point: | 231.0 to 235.0 °C |
| Boiling point: | 521.5±60.0 °C(Predicted) |
| Density | 1.223±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 7.11±0.10(Predicted) |
| color | Off-White |
| Water Solubility | Water: Insoluble |
| λmax | 287nm(CHCl3)(lit.) |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 6981-18-6(CAS DataBase Reference) |
| EPA Substance Registry System | Ormetoprim (6981-18-6) |
Safety information for 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
New Products
9-Mesityl-10-methylacridinium perchlorate Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde 4 pentyn 1 ol N-Vinylformamide Phenethyl cinnamate Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Ethyl 3-phenylpropanoate β-Bromostyrene Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 5-Bromo-1-Pentyne 1-(2-Methyl-5-nitrophenyl)guanidine Nitrate Methyl trans-4-Aminocyclohexanecarboxylate Hydrochloride N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide 4-Nitrobenzotrifluoride 2-Pentyn-1-oLRelated products of tetrahydrofuran
You may like
-
Ormetoprim 98% CAS 6981-18-6View Details
6981-18-6 -
1191-95-3 Cyclobutanone 98+View Details
1191-95-3 -
Fmoc-OSu 98+View Details
82911-69-1 -
(R)-(-)-2-Amino-1-propanol 35320-23-1 98+View Details
35320-23-1 -
1191-95-3 Cyclobutanone 98+View Details
1191-95-3 -
213382-45-7 98+View Details
213382-45-7 -
Fmoc-OSu 98+View Details
82911-69-1 -
(R)-(-)-2-Amino-1-propanol 35320-23-1 98+View Details
35320-23-1
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.