5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
- CAS NO.：6981-18-6
- Empirical Formula: C14H18N4O2
- Molecular Weight: 274.32
- MDL number: MFCD00057747
- EINECS: 230-246-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-09 18:56:23
What is 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine?
The Uses of 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.
The Uses of 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.This compound is a contaminant of emerging concern (CECs).
Definition
ChEBI: 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine is a dimethoxybenzene.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 14, p. 462, 1971 DOI: 10.1021/jm00287a029
Properties of 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
| Melting point: | 231.0 to 235.0 °C |
| Boiling point: | 521.5±60.0 °C(Predicted) |
| Density | 1.223±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 7.11±0.10(Predicted) |
| color | Off-White |
| Water Solubility | Water: Insoluble |
| λmax | 287nm(CHCl3)(lit.) |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 6981-18-6(CAS DataBase Reference) |
| EPA Substance Registry System | Ormetoprim (6981-18-6) |
Safety information for 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
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