Xanomeline
Synonym(s):3-Hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole;Lomeron;LY-246708;Memcor
- CAS NO.：131986-45-3
- Empirical Formula: C14H23N3OS
- Molecular Weight: 281.42
- MDL number: MFCD00867179
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-29 15:22:00
What is Xanomeline?
Description
Xanomeline is used as a potent and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist to increase neuronal excitability. Xanomeline is used in studies of neurological disorders such as Alzheimer's disease and schizophrenia. However, development of the drug was halted due to severe cholinergic adverse effects. Currently, xanomeline-trospium (KarXT) (a peripheral cholinergic antagonist) has been explored for the treatment of schizophrenia and a New Drug Application has been filed with the FDA, with a decision on whether it will be approved or not expected on 26 September 2024.
The Uses of Xanomeline
Alzheimer’s disease treatment (cholinergic agonist).
Definition
ChEBI: Xanomeline is a member of thiadiazoles and a tetrahydropyridine. It has a role as a muscarinic agonist and a serotonergic agonist.
Mechanism of action
Xanomeline's mechanism of action is is to rebalance key neurotransmitter circuits, including acetylcholine, dopamine and glutamate, which are disrupted in schizophrenia and related disorders.
Properties of Xanomeline
| Boiling point: | 397.0±42.0 °C(Predicted) |
| Density | 1.101±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | H2O: soluble10mg/mL, clear (warmed) |
| form | powder |
| pka | 7.34±0.40(Predicted) |
| color | off-white |
Safety information for Xanomeline
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for Xanomeline
| InChIKey | JOLJIIDDOBNFHW-UHFFFAOYSA-N |
Xanomeline manufacturer
LUPA PHARMACEUTICALS
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