Xanomeline

Synonym(s):3-Hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole;Lomeron;LY-246708;Memcor

CAS NO.：131986-45-3
Empirical Formula: C14H23N3OS
Molecular Weight: 281.42
MDL number: MFCD00867179
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-04 16:42:01

What is Xanomeline?

Description

Xanomeline is used as a potent and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist to increase neuronal excitability. Xanomeline is used in studies of neurological disorders such as Alzheimer's disease and schizophrenia. However, development of the drug was halted due to severe cholinergic adverse effects. Currently, xanomeline-trospium (KarXT) (a peripheral cholinergic antagonist) has been explored for the treatment of schizophrenia and a New Drug Application has been filed with the FDA, with a decision on whether it will be approved or not expected on 26 September 2024.

The Uses of Xanomeline

Alzheimer’s disease treatment (cholinergic agonist).

Definition

ChEBI: Xanomeline is a member of thiadiazoles and a tetrahydropyridine. It has a role as a muscarinic agonist and a serotonergic agonist.

Mechanism of action

Xanomeline's mechanism of action is is to rebalance key neurotransmitter circuits, including acetylcholine, dopamine and glutamate, which are disrupted in schizophrenia and related disorders.

Properties of Xanomeline

Boiling point:	397.0±42.0 °C(Predicted)
Density	1.101±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	H2O: soluble10mg/mL, clear (warmed)
form	powder
pka	7.34±0.40(Predicted)
color	off-white

Safety information for Xanomeline

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.