4,5-Dimethoxy-2-nitrobenzyl bromide
Synonym(s):6-Nitroveratryl bromide
- CAS NO.：53413-67-5
- Empirical Formula: C9H10BrNO4
- Molecular Weight: 276.08
- MDL number: MFCD00192064
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-11-04 17:04:05
What is 4,5-Dimethoxy-2-nitrobenzyl bromide?
The Uses of 4,5-Dimethoxy-2-nitrobenzyl bromide
4,5-Dimethoxy-2-nitrobenzyl bromide (DMNB bromide, 6-nitroveratryl bromide) is suitable reagent used in the synthesis of N-(4,5-dimethoxy-2-nitrobenzyl)vanillylamine which forms caged vanilloid. It may be used in the synthesis of the following:
- 4-(4′,5′-dimethoxy-2-nitrobenzyloxy)benzaldehyde, a DMNB-caged aldehyde
- N-[4-[(4,5-dimethoxy-2-nitrobenzyl)oxy]-3-methoxybenzyl]acetamide
- caged derivative of pyridostatin ([C]-PDS)
- photosensitive polyimide (PI-DMNB)
- caged β-ecdysone
- 4-tert-butyldimethylsilyloxy-1-(2-deoxy-3,5-di-O-toluoyl-β-D-ribofuranosyl)-2-(6-nitroveratrylthio)-1H-benzimidazole, an intermediate in synthesis of phosphoramidite bearing 4-hydroxy-2-mercaptobenzimidazole (SBNV) nucleobase
- alkylation of dihydrofluorescein
- 4-(4′,5′-Dimethoxy-2′-nitrobenzyloxy)benzaldehyde
The Uses of 4,5-Dimethoxy-2-nitrobenzyl bromide
1-(Bromomethyl)-4,5-dimethoxy-2-nitrobenzene is a useful research chemical.
General Description
4,5-Dimethoxy-2-nitrobenzyl bromide (DMNBB, 1-(Bromomethyl)-4,5-dimethoxy-2-nitrobenzene) is a 4,5-dimethoxy-2-nitrobenzyl derivative. 4,5-Dimethoxy-2-nitrobenzyl (DMNB) group of DMNBB is used as a photolabile protecting group in caging technology to develop pro-drugs. Synthesis of 1-(bromomethyl)-4,5-dimethoxy-2-nitrobenzene by using 6-nitroveratraldehyde as starting reagent has been reported.
Properties of 4,5-Dimethoxy-2-nitrobenzyl bromide
| Melting point: | 131-133 °C (lit.) |
| Boiling point: | 372.3±37.0 °C(Predicted) |
| Density | 1.544 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | Crystalline Powder or Needles |
| color | Yellow to brown |
| Sensitive | Lachrymatory |
Safety information for 4,5-Dimethoxy-2-nitrobenzyl bromide
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4,5-Dimethoxy-2-nitrobenzyl bromide
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