2-Nitrobenzyl bromide
Synonym(s):α-Bromo-2-nitrotoluene
- CAS NO.:3958-60-9
- Empirical Formula: C7H6BrNO2
- Molecular Weight: 216.03
- MDL number: MFCD00007184
- EINECS: 223-558-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-04 16:00:12
What is 2-Nitrobenzyl bromide?
Chemical properties
white to light yellow crystal powde
The Uses of 2-Nitrobenzyl bromide
2-Nitrobenzyl bromide is used in the preparation of S-2-nitrobenzyl-cysteine by reaction with L-cysteine. It is also used for the introduction of the 2-nitrobenzyl protecting group in organic synthesis. It plays an important role in the production of expectorant agent. Further, it is employed for caging unprotected cysteine-containing or thiophosphorylated peptides in aqueous solution. In addition to this, it is used in the preparation of (R)- and (S)-3-amino-3,4-dihydro-1H-quinolin-2-one.
The Uses of 2-Nitrobenzyl bromide
2-Nitrobenzyl bromide was used for caging unprotected cysteine-containing or thiophosphorylated peptides in aqueous solution. It can be used in the synthesis of (R)- and (S)-3-amino-3,4-dihydro-1H-quinolin-2-one.
What are the applications of Application
2-Nitrobenzyl bromide is a reagent used for caging unprotected cysteine and thiophosphoryl peptides in aqueous solution
Biochem/physiol Actions
2-Nitrobenzyl bromide reacts with L-cysteine to form S-2-nitrobenzyl-cysteine which was used for modification of ultra-low-gelling-temperature (ULGT) agarose.
Properties of 2-Nitrobenzyl bromide
| Melting point: | 44-46 °C (lit.) |
| Boiling point: | 265.51°C (rough estimate) |
| Density | 1.6841 (rough estimate) |
| refractive index | 1.6120 (estimate) |
| Flash point: | >230 °F |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) |
| form | Crystals or Crystalline Powder |
| color | Yellow to light brown |
| Water Solubility | insoluble |
| BRN | 638991 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 3958-60-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Nitrobenzyl bromide(3958-60-9) |
Safety information for 2-Nitrobenzyl bromide
| Signal word | Danger |
| Pictogram(s) |
![]() Corrosion Corrosives GHS05 ![]() Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
Computed Descriptors for 2-Nitrobenzyl bromide
2-Nitrobenzyl bromide manufacturer
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