4,4'-OXYBIS(PHENYL ISOCYANATE)

CAS NO.：4128-73-8
Empirical Formula: C14H8N2O3
Molecular Weight: 252.22
MDL number: MFCD00216648
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-31 14:38:37

What is 4,4'-OXYBIS(PHENYL ISOCYANATE)?

Chemical properties

WHITE CRYSTALLINE SOLID

The Uses of 4,4'-OXYBIS(PHENYL ISOCYANATE)

4,4'-Bis(isocyanatophenyl)oxide is a reagent used in the synthesis of lipid-conjugated Smac analogs with antitumor activity against human breast cancer cell lines.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.

Reactivity Profile

Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Polyurethanes are formed by the condensation reaction of diisocyanates with, for example, ethyl glycol.

Properties of 4,4'-OXYBIS(PHENYL ISOCYANATE)

Melting point:	64-68 °C(lit.)
Boiling point:	196 °C5 mm Hg(lit.)
Density	1.2700 (rough estimate)
refractive index	1.5910 (estimate)
solubility	Acetonitrile (Soluble)
form	Solid
color	White to Off-White
Stability:	Moisture Sensitive
CAS DataBase Reference	4128-73-8
EPA Substance Registry System	4,4'-Diisocyanatodiphenyl ether (4128-73-8)

Safety information for 4,4'-OXYBIS(PHENYL ISOCYANATE)

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H301:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H330:Acute toxicity,inhalation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P310:Immediately call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.