4-Methoxyphenyl isocyanate
- CAS NO.：5416-93-3
- Empirical Formula: C8H7NO2
- Molecular Weight: 149.15
- MDL number: MFCD00002026
- EINECS: 226-513-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:45:38
What is 4-Methoxyphenyl isocyanate?
Chemical properties
clear colorless liquid
The Uses of 4-Methoxyphenyl isocyanate
4-Methoxyphenyl isocyanate has been used in the preparation of:
- 6H-indolo[2,3-b]quinolines
- 1-[2-(2-furyl)-8-methyl-9-substituted-8H-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c] pyrimidin-5-yl]-3-(4-methoxyphenyl)urea
Synthesis Reference(s)
Tetrahedron Letters, 17, p. 2691, 1976 DOI: 10.1016/S0040-4039(00)77797-5
General Description
Cyclotrimerization of 4-methoxyphenyl isocyanate by CO2-protected N-heterocyclic carbenes based on tetrahydropyrimidin-2-ylidenes has been reported.
Properties of 4-Methoxyphenyl isocyanate
| Melting point: | 101 °C |
| Boiling point: | 106-110 °C16 mm Hg(lit.) |
| Density | 1.151 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 209 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Chloroform, Methanol |
| form | Liquid |
| Specific Gravity | 1.151 |
| color | Clear colorless |
| Sensitive | Moisture Sensitive |
| BRN | 471920 |
| CAS DataBase Reference | 5416-93-3(CAS DataBase Reference) |
| NIST Chemistry Reference | P-methoxy phenyl isocyanate(5416-93-3) |
| EPA Substance Registry System | Benzene, 1-isocyanato-4-methoxy- (5416-93-3) |
Safety information for 4-Methoxyphenyl isocyanate
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H317:Sensitisation, Skin H334:Sensitisation, respiratory |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Methoxyphenyl isocyanate
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