4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID
Synonym(s):4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na;DIDS, Disodium Salt - CAS 53005-05-3 - Calbiochem
- CAS NO.：53005-05-3
- Empirical Formula: C16H10N2O6S4
- Molecular Weight: 454.52
- MDL number: MFCD00065493
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:39
What is 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID?
Chemical properties
Yellow Crystalline Solid
The Uses of 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID
Stilbene disulfonates have been employed to inhibit anion transport in a large number of mammalian cell types (GABA, Cl-). Some stilbene disulfonates can bind specifically to proteins that are not anion transporters. DIDS reacts with CD4 glycoprot
The Uses of 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID
Ion channel inhibitor; especially of anion transport.
Definition
ChEBI: 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid is an arenesulfonic acid.
General Description
Binds covalently and irreversibly to the outer surface of human erythrocyte membranes. Inhibits ATP transport into endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl– uptake (IC50 = 150 nM) in neuroblastoma cells. Has anti-ulcerous properties.
Biochem/physiol Actions
Primary TargetCl- uptake
Properties of 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID
| Melting point: | >400°C |
| Density | 1.54±0.1 g/cm3(Predicted) |
| pka | -1.32±0.50(Predicted) |
Safety information for 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID
Computed Descriptors for 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID
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