4,4'-DI-TERT-BUTYLBIPHENYL

CAS NO.：1625-91-8
Empirical Formula: C20H26
Molecular Weight: 266.42
MDL number: MFCD00008834
EINECS: 216-615-4
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-04 14:25:31

What is 4,4'-DI-TERT-BUTYLBIPHENYL?

Chemical properties

Powder

The Uses of 4,4'-DI-TERT-BUTYLBIPHENYL

It is used in the generation of 1,2-di(lithiomethyl)benzene. It is found to accept electrons from Li metal to give a radical anion which is highly effective in the conversion of alkyl halides to alkyllithiums. 4,4?-Di-tert-butylbiphenyl is used in production of homoallylic amine derivatives. It is also used in the preparation of lithium di-tert-butylbiphenylide, a radical anion, superior to sodium or lithium naphthalenides for metalation reactions. Along with lithium, 4,4?-Di-tert-butylbiphenyl catalyzes; reaction of chloromethyl ethyl ether and different carbonyl compounds to yield corresponding hydroxyethers and reductive opening of N-phenylazetidine.

Synthesis Reference(s)

Tetrahedron Letters, 26, p. 1655, 1985 DOI: 10.1016/S0040-4039(00)98576-9

General Description

4,4′-Di-tert-butylbiphenyl along with lithium catalyzes:

reaction of chloromethyl ethyl ether and different carbonyl compounds to yield corresponding hydroxyethers
reductive opening of N-phenylazetidine

Properties of 4,4'-DI-TERT-BUTYLBIPHENYL

Melting point:	126-130 °C(lit.)
Boiling point:	190-192 °C13 mm Hg(lit.)
Density	0.9463 (estimate)
refractive index	1.5928 (estimate)
Flash point:	190-192°C/13mm
storage temp.	Sealed in dry,Room Temperature
solubility	dioxane: 0.1 g/mL, clear
form	Crystalline Powder
color	Light yellow to yellow-orange
BRN	2095855
CAS DataBase Reference	1625-91-8(CAS DataBase Reference)
NIST Chemistry Reference	4,4'-Di-tert-butylbiphenyl(1625-91-8)