4-Methylpyridazine
- CAS NO.：1120-88-3
- Empirical Formula: C5H6N2
- Molecular Weight: 94.11
- MDL number: MFCD00011594
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:28
What is 4-Methylpyridazine?
Chemical properties
Clear yellow liquid
The Uses of 4-Methylpyridazine
4-Methylpyridazine was used in the preparation of series of novel pyridazine derivatives structurally related to bipyridine cardiotonics.
Reactions
4-methylpyridazine could be used as a starting material to synthesize a series of novel pyridazine derivatives structurally related to bipyridine cardiotonics[1].
Pyridazine (pydz) and 4-methylpyridazine (4Me-pydz) could form stable bis(monodentate) complexes of general formulae fac-[PtXMe3L2](X = Cl, Br or I) and fac-[ReX(CO)3L2](X = Cl, Br or I). These complexes in above-ambient temperature solutions exhibit 1,2-fluxional shifts between the nitrogen donor pairs of each ring[2].
General Description
Products of reaction of methyl iodide with 4-methylpyridazine has been investigated by NMR spectra. Solvent free oxidation of 4-methylpyridazine by acetyl peroxyborate, peracetic acid and hydrogen peroxide has been reported.
References
[1] Haider N, et al. Pyridazine analogues of biologically active compounds. Part 5: Novel potential cardiotonics of the amrinone type. Organic Electronics, 1989.
[2] Abel E, et al. 1,2-Metallotropic shifts in trimethylplatinum(IV) and tricarbonylrhenium(I) halide complexes of pyridazine and 4-methylpyridazine. Journal of the Chemical Society, Dalton Transactions, 1994; 445-455.
Properties of 4-Methylpyridazine
| Boiling point: | 98-100 °C/11 mmHg (lit.) |
| Density | 1.06 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 222 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | Liquid |
| pka | 3.74±0.10(Predicted) |
| Specific Gravity | 1.060 |
| color | Clear yellow |
| λmax | 292nm(H2O)(lit.) |
| BRN | 105689 |
| InChI | InChI=1S/C5H6N2/c1-5-2-3-6-7-4-5/h2-4H,1H3 |
| CAS DataBase Reference | 1120-88-3(CAS DataBase Reference) |
Safety information for 4-Methylpyridazine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Methylpyridazine
| InChIKey | AIKUBOPKWKZULG-UHFFFAOYSA-N |
| SMILES | C1=NN=CC=C1C |
4-Methylpyridazine manufacturer
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