4-Methylaniline hydrochloride
Synonym(s):4-Methylaniline hydrochloride
- CAS NO.：540-23-8
- Empirical Formula: C7H10ClN
- Molecular Weight: 143.61
- MDL number: MFCD00035497
- EINECS: 208-740-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:12
What is 4-Methylaniline hydrochloride?
Chemical properties
white to light beige crystalline powder, crystals
The Uses of 4-Methylaniline hydrochloride
p-Toluidine Hydrochloride acts as a reagent for the preparation and biological activity of N-acylleucine (arylaminoethyl)amides as non-covalent inhibitors of cathepsin K, L and S. Catalyst in the chemistry of azasteroids.
What are the applications of Application
p-Toluidine hydrochloride is a toluene derivative for proteomics research
General Description
Off-white to grayish-white crystals.
Air & Water Reactions
Water soluble. May be sensitive to moisture.
Reactivity Profile
4-Methylaniline hydrochloride reacts with oxidizing and alkali materials. .
Fire Hazard
Flash point data for 4-Methylaniline hydrochloride are not available, but 4-Methylaniline hydrochloride is probably combustible.
Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also p-TOLUIDINE.
Purification Methods
Crystallise the salt from MeOH containing a few drops of conc HCl or aqueous EtOH. Dry it under vacuum over paraffin chips. [Beilstein 12 II 587, 12 III 2021, 12 IV 1869.]
Properties of 4-Methylaniline hydrochloride
| Melting point: | 243-245 °C(lit.) |
| Density | 1.193 g/cm3 |
| storage temp. | Store below +30°C. |
| Water Solubility | Soluble in water |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| form | powder to crystal |
| color | White to Gray to Red |
| BRN | 3557540 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 540-23-8(CAS DataBase Reference) |
| EPA Substance Registry System | p-Toluidine hydrochloride (540-23-8) |
Safety information for 4-Methylaniline hydrochloride
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08  Environment GHS09 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H351:Carcinogenicity H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Methylaniline hydrochloride
New Products
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