4-Methyl-1,2,4-triazoline-3,5-dione
- CAS NO.：13274-43-6
- Empirical Formula: C3H3N3O2
- Molecular Weight: 113.07
- MDL number: MFCD00013440
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:49:13
What is 4-Methyl-1,2,4-triazoline-3,5-dione?
The Uses of 4-Methyl-1,2,4-triazoline-3,5-dione
4-METHYL-1,2,4-TRIAZOLINE-3,5-DIONE is a dienophile used in the partial elucidation of Trichogramma putative sex pheromone at trace levels.
Synthesis Reference(s)
The Journal of Organic Chemistry, 31, p. 3444, 1966 DOI: 10.1021/jo01348a532
Synthetic Communications, 17, p. 409, 1987 DOI: 10.1080/00397918708063918
Purification Methods
MTAD is obtained as pink needles by sublimation at 40-50o/0.1mm (see 4-phenyl-1,2,4-triazoline-3,5-dione, PTAD below). [Cookson et al. Org Synth 51 121 1971, Cheng et al. J Org Chem 49 2910 1984, Beilstein 26 III/IV 538.]
Properties of 4-Methyl-1,2,4-triazoline-3,5-dione
| Melting point: | 107-109 °C(lit.) |
| Boiling point: | 137.5±23.0 °C(Predicted) |
| Density | 1.71±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol |
| form | Solid |
| pka | -3.61±0.20(Predicted) |
| color | Pink to Dark Pink |
| Stability: | Hygroscopic, Temperature Sensitive, Unstable in Solution |
Safety information for 4-Methyl-1,2,4-triazoline-3,5-dione
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Methyl-1,2,4-triazoline-3,5-dione
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