4-Methoxypyridine

CAS NO.：620-08-6
Empirical Formula: C6H7NO
Molecular Weight: 109.13
MDL number: MFCD00674049
EINECS: 210-624-7
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 03:41:01

What is 4-Methoxypyridine?

Chemical properties

clear colorless to slightly yellow liquid

The Uses of 4-Methoxypyridine

4-Methoxypyridine, is used as a building block for the synthesis of some biologically active compounds. It is used for the preparation of a new series of benzoylated N-ylides as protein farnesyltransferase inhibitors.

The Uses of 4-Methoxypyridine

4-Methoxypyridine was used as a starting reagent for the stereocontrolled synthesis of (±)-pumiliotoxin C and (±)-lasubine II. It was also used in an efficient construction of dihyropyridin-4-ones, which serves as potential ligands for neuronal nicotinic acetycholine receptors.

General Description

4-Methoxypyridine has been prepared from 4-methoxypyridine-N-oxide, via catalytic hydrogenation. Ortho lithiation of 4-methoxypyridine using mesityllithium as the metalating base has been studied.

Properties of 4-Methoxypyridine

Melting point:	4 °C
Boiling point:	108-111 °C/65 mmHg (lit.)
Density	1.075 g/mL at 25 °C (lit.)
refractive index	1.518-1.522
Flash point:	74 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Liquid
pka	6.58(at 25℃)
Specific Gravity	1.075
color	Clear colorless to slightly yellow
BRN	108211
CAS DataBase Reference	620-08-6(CAS DataBase Reference)
NIST Chemistry Reference	Pyridine, 4-methoxy-(620-08-6)

Safety information for 4-Methoxypyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.