4-HYDROXYANTIPYRINE

Synonym(s):4-Hydroxy-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one;NSC 174055

CAS NO.：1672-63-5
Empirical Formula: C11H12N2O2
Molecular Weight: 204.23
MDL number: MFCD00003143
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-05 14:33:18

What is 4-HYDROXYANTIPYRINE?

The Uses of 4-HYDROXYANTIPYRINE

4-Hydroxyantipyrine is a metabolite of antipyrine (A697500) which is an analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.

The Uses of 4-HYDROXYANTIPYRINE

Antipyrine metabolite

The Uses of 4-HYDROXYANTIPYRINE

4-Hydroxyantipyrine was used to study the relationships between the metabolism of antipyrine, hexobarbitone and theophylline in man. It was used in a study on flow injection analysis system for the characterisation of pharmaceutical compounds via combination of diode array UV, 1H NMR, FT-IR spectroscopy and time-of-flight mass spectrometry.

Definition

ChEBI: 4-hydroxy-1,5-dimethyl-2-phenyl-3-pyrazolone is a ring assembly and a member of pyrazoles.

General Description

4-Hydroxyantipyrine is formed during oxidative deamination of aminopyrine. It is a metabolite of antipyrine.

Properties of 4-HYDROXYANTIPYRINE

Melting point:	184-186 °C (lit.)
Boiling point:	314.3±52.0 °C(Predicted)
Density	1.294±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	DMSO (Slightly), Methanol (Slightly)
form	neat
pka	11.99±0.20(Predicted)
form	Solid
color	Off-White to Beige

Safety information for 4-HYDROXYANTIPYRINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.