4-Hydroxy-6-methyl-2-pyrone
Synonym(s):3,5-Dihydroxysorbic acid δ-lactone
- CAS NO.：675-10-5
- Empirical Formula: C6H6O3
- Molecular Weight: 126.11
- MDL number: MFCD00006641
- EINECS: 211-619-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 05:50:00
What is 4-Hydroxy-6-methyl-2-pyrone?
Chemical properties
white to light yellow crystal powder
The Uses of 4-Hydroxy-6-methyl-2-pyrone
4-Hydroxy-6-methylpyran-2-one was used in the synthesis of pyrano[3,2-c]pyridones with antiproliferative and apoptosis inducing activities. It was also used in the design of benzisothiazolone human leukocyte elastase inhibitors.
Definition
ChEBI: Triacetate lactone is a member of 2-pyranones. It is a conjugate acid of a triacetate lactone oxoanion.
Synthesis Reference(s)
Synthetic Communications, 20, p. 1931, 1990 DOI: 10.1080/00397919008053123
Properties of 4-Hydroxy-6-methyl-2-pyrone
| Melting point: | 188-190 °C (dec.) (lit.) |
| Boiling point: | 174.21°C (rough estimate) |
| Density | 1.2048 (rough estimate) |
| refractive index | 1.4189 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | 8.6g/l |
| pka | 5.14±0.30(Predicted) |
| form | Powder |
| color | Off-white to brown |
| Water Solubility | 8.60 g/L (20 ºC) |
| BRN | 113815 |
| CAS DataBase Reference | 675-10-5(CAS DataBase Reference) |
| EPA Substance Registry System | 2H-Pyran-2-one, 4-hydroxy-6-methyl- (675-10-5) |
Safety information for 4-Hydroxy-6-methyl-2-pyrone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Hydroxy-6-methyl-2-pyrone
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