4'-Fluoro-2'-hydroxyacetophenone
- CAS NO.：1481-27-2
- Empirical Formula: C8H7FO2
- Molecular Weight: 154.14
- MDL number: MFCD00143203
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-25 15:33:52
What is 4'-Fluoro-2'-hydroxyacetophenone?
Chemical properties
Colorless to yellow liquid
The Uses of 4'-Fluoro-2'-hydroxyacetophenone
4′-Fluoro-2′-hydroxyacetophenone may be used in the preparation of series of 4′-fluoro-2′-hydroxychalcones, via aldol condensation with substituted aldehydes followed by cyclization with hydrazine hydrate.
Preparation
Preparation by Fries rearrangement of 3-fluorophenyl acetate with aluminium chloride without solvent at 160–180° (75%) (88–90%).
General Description
4′-Fluoro-2′-hydroxyacetophenone is a substituted acetophenone derivative. Biological Baeyer-Villiger oxidation of 4′-fluoro-2′-hydroxyacetophenone to 4-fluorocatechol by using whole cells of Pseudomonas fluorescens ACB has been reported. Its crystals belong to the monoclinic crystal system and space group P21/n.
Properties of 4'-Fluoro-2'-hydroxyacetophenone
| Melting point: | 32-34°C |
| Boiling point: | 65°C 2mm |
| Density | 1.1850 (estimate) |
| Flash point: | 98°C |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to lump |
| pka | 9.17±0.10(Predicted) |
| color | White to Almost white |
| BRN | 2249799 |
| CAS DataBase Reference | 1481-27-2(CAS DataBase Reference) |
Safety information for 4'-Fluoro-2'-hydroxyacetophenone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4'-Fluoro-2'-hydroxyacetophenone
| InChIKey | HLTBTUXAMVOKIH-UHFFFAOYSA-N |
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