4'-Fluoro-2'-hydroxyacetophenone
- CAS NO.：1481-27-2
- Empirical Formula: C8H7FO2
- Molecular Weight: 154.14
- MDL number: MFCD00143203
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-25 15:33:52
What is 4'-Fluoro-2'-hydroxyacetophenone?
Chemical properties
Colorless to yellow liquid
The Uses of 4'-Fluoro-2'-hydroxyacetophenone
4′-Fluoro-2′-hydroxyacetophenone may be used in the preparation of series of 4′-fluoro-2′-hydroxychalcones, via aldol condensation with substituted aldehydes followed by cyclization with hydrazine hydrate.
Preparation
Preparation by Fries rearrangement of 3-fluorophenyl acetate with aluminium chloride without solvent at 160–180° (75%) (88–90%).
General Description
4′-Fluoro-2′-hydroxyacetophenone is a substituted acetophenone derivative. Biological Baeyer-Villiger oxidation of 4′-fluoro-2′-hydroxyacetophenone to 4-fluorocatechol by using whole cells of Pseudomonas fluorescens ACB has been reported. Its crystals belong to the monoclinic crystal system and space group P21/n.
Properties of 4'-Fluoro-2'-hydroxyacetophenone
| Melting point: | 32-34°C |
| Boiling point: | 65°C 2mm |
| Density | 1.1850 (estimate) |
| Flash point: | 98°C |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to lump |
| pka | 9.17±0.10(Predicted) |
| color | White to Almost white |
| BRN | 2249799 |
| CAS DataBase Reference | 1481-27-2(CAS DataBase Reference) |
Safety information for 4'-Fluoro-2'-hydroxyacetophenone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4'-Fluoro-2'-hydroxyacetophenone
| InChIKey | HLTBTUXAMVOKIH-UHFFFAOYSA-N |
New Products
Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 2-Bromo-5-hydroxybenzoic acid. 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 4-Fluorophenylglycine 1-N-Boc-3-(aminoethyl)azetidine Dimedone 1-Boc-3-(cyanomethyl)azetidine N-BOC-piperidine-4-carboxylic acid 1-Benzhydrylazetane-3-carbonitrile 5-Amino-2-Hydroxypyridine 2-Amino-5-Iodopyridine 2-BROMOACETYL BROMIDE-D2 METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3 6-Chloro-pyrimidine-2,4-diamine 3-Oxide 1-Acetyl-4-(4-hydroxyphenyl)piperazine 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
You may like
-
1481-27-2 4'-Fluoro-2'-hydroxyacetophenone 98%View Details
1481-27-2 -
4'-Fluoro-2'-hydroxyacetophenone CAS 1481-27-2View Details
1481-27-2 -
4′-Fluoro-2′-hydroxyacetophenone CAS 1481-27-2View Details
1481-27-2 -
1-(4-Aminophenyl)-4-(4-methoxyphenyl)Piperazine 74852-62-3View Details
74852-62-3 -
5-Bromo-2-Chlorobenzoic acid 21739-92-4View Details
21739-92-4 -
36476-86-5 1-Benzhydrylazetane-3-carbonitrile 98+View Details
36476-86-5 -
36476-86-5 1-Benzhydrylazetane-3-carbonitrile 98+View Details
36476-86-5 -
36476-86-5 1-Benzhydrylazetane-3-carbonitrile 98+View Details
36476-86-5
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.