4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
- CAS NO.：17129-06-5
- Empirical Formula: C6H7F3O2
- Molecular Weight: 168.11
- MDL number: MFCD00192131
- EINECS: 629-004-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 03:02:42
What is 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one?
Chemical properties
light yellow liquid
The Uses of 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one may be used in the synthesis of 4-dialkylamino-1,1,1-trifluorobut-3-ene-2-ones. It may be used for the synthesis of β-alkyl- or dialkylamino substituted enones bearing a CF3 group.
General Description
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one reacts with phenylmagnesium bromide to afford ethoxy group substitution products, while it reacts with organozinc compounds to yield products arising from 1,2-addition to the carbonyl group. 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one on heating with triethyl phosphite affords [4+2] cycloaddition product, 2,2,2-triethoxy 2,3-dihydro-3-ethoxy-5-trifluoromethyl-1,2λ5-oxaphospholene, which on hydrolysis affords a 2-oxo-2-hydroxy-2, 3-dihydro-3-hydroxy 5-trifluoromethyl-1,2λ5-oxaphospholen. It reacts with amino to give the N-protected amino acids, which is useful for the peptide synthesis.
Properties of 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
| Melting point: | -30℃ |
| Boiling point: | 51-53 °C/12 mmHg (lit.) |
| Density | 1.18 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 125 °F |
| storage temp. | 2-8°C |
| solubility | soluble in Chloroform, Methanol |
| form | Liquid |
| color | Colorless to yellow |
| Sensitive | Moisture Sensitive |
| CAS DataBase Reference | 17129-06-5(CAS DataBase Reference) |
Safety information for 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Health Hazard GHS08 |
| GHS Hazard Statements |
H226:Flammable liquids H351:Carcinogenicity H412:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P273:Avoid release to the environment. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
| InChIKey | YKYIFUROKBDHCY-ONEGZZNKSA-N |
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