4-Chlorothiophenol
Synonym(s):4-Chlorobenzenethiol;4-Chlorophenyl mercaptan
- CAS NO.：106-54-7
- Empirical Formula: C6H5ClS
- Molecular Weight: 144.62
- MDL number: MFCD00004847
- EINECS: 203-408-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:38
What is 4-Chlorothiophenol?
Chemical properties
white to almost white crystalline solid
The Uses of 4-Chlorothiophenol
4-Chlorothiophenol was used to modify poly(vinyl chloride) and to synthesize poly(vinyl chloride) with halogen groups.
The Uses of 4-Chlorothiophenol
Oil additives, agricultural chemicals, plasticizers, rubber chemical, dyes, wetting agents, and stabilizers.
Synthesis Reference(s)
The Journal of Organic Chemistry, 27, p. 4455, 1962 DOI: 10.1021/jo01059a081
Synthetic Communications, 18, p. 575, 1988 DOI: 10.1080/00397918808064014
General Description
4-Chlorothiophenol undergoes oxidative coupling catalyzed by iron(III)-tetra phenyl prophyrin to form disulfides.
Hazard
Toxic by ingestion.
Purification Methods
Recrystallise the thiophenol from aqueous EtOH. The SMe ether has m 129o and the SEt ether has m 64o. [D'Sousa et al. J Org Chem 52 1720 1987, Beilstein 6 H 326, 6 I 149, 6 III 1034.]
Properties of 4-Chlorothiophenol
| Melting point: | 49-51 °C(lit.) |
| Boiling point: | 205-207 °C(lit.) |
| Density | 1.1911 |
| refractive index | 1.5480 |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| solubility | methanol: soluble |
| form | Crystalline Solid |
| pka | pK1:5.9 (25°C) |
| color | White to almost white |
| Water Solubility | insoluble |
| Sensitive | Stench/Lachrymatory |
| BRN | 605971 |
| CAS DataBase Reference | 106-54-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzenethiol, 4-chloro-(106-54-7) |
| EPA Substance Registry System | Benzenethiol, 4-chloro- (106-54-7) |
Safety information for 4-Chlorothiophenol
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Chlorothiophenol
| InChIKey | VZXOZSQDJJNBRC-UHFFFAOYSA-N |
4-Chlorothiophenol manufacturer
Stratechem (India) Private Limited
Mumbai
product: Para Chloro Thio Phenol, Purity: 98% Min., Packaging Type: HDPE Drums
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