4-Chlorobenzyl chloride

Synonym(s):α,4-Dichlorotoluene;(4-Chlorophenyl)methyl chloride;1-Chloro-4-(chloromethyl)benzene;NSC 34032

CAS NO.：104-83-6
Empirical Formula: C7H6Cl2
Molecular Weight: 161.03
MDL number: MFCD00000914
EINECS: 203-242-7
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:26:30

What is 4-Chlorobenzyl chloride?

Chemical properties

Colorless to light yellow liqui

The Uses of 4-Chlorobenzyl chloride

4-Chlorobenzyl Chloride is a benzylchloride derivative used in the preparation of various biologically active compounds such as bronchodilators and antibacterial agents.

The Uses of 4-Chlorobenzyl chloride

Reagent used in derivatization of, for example, a calix[4]arene1 and a tryptamine.2

The Uses of 4-Chlorobenzyl chloride

4-Chlorobenzyl chloride was the test compound for determining rat hepatocellular thiols by HPLC. As a reagent used in derivatization of, for example, a calix[4]arene and a tryptamine. It is widely used as an intermediate for manufacturing organic compounds like benzyl alcohol and benzyl cyanide. Also used in fuel as a gum inhibitor.

What are the applications of Application

4-Chlorobenzyl chloride is A reagent used in derivatization

General Description

4-Chlorobenzyl chloride is generally used in the preparation of quaternary ammonium salts. It acts as an intermediate in the production of rice herbicide, pharmaceuticals and pesticides.

Hazard

Irritating to skin, eyes.

Purification Methods

Dry it over CaSO4, then fractionally distil it under reduced pressure. Crystallise it from heptane or dry diethyl ether at low temperature. [Beilstein 5 IV 816.] LACHRYMATORY.

Properties of 4-Chlorobenzyl chloride

Melting point:	27-29 °C (lit.)
Boiling point:	216-222 °C (lit.)
Density	1.26
Flash point:	208 °F
refractive index	1.5575
storage temp.	Store at RT.
solubility	insoluble
form	Crystalline Low Melting Solid
Specific Gravity	1.26
color	Colorless to white
Water Solubility	insoluble
Sensitive	Lachrymatory
BRN	471558
Stability:	Moisture Sensitive
CAS DataBase Reference	104-83-6(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1-chloro-4-(chloromethyl)-(104-83-6)
EPA Substance Registry System	4-Chlorobenzyl chloride (104-83-6)

Safety information for 4-Chlorobenzyl chloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H317:Sensitisation, Skin H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.