4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE
- CAS NO.：162012-70-6
- Empirical Formula: C8H3ClFN3O2
- Molecular Weight: 227.58
- MDL number: MFCD08063159
- EINECS: 000-000-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 00:47:59
What is 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE?
The Uses of 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE
4-Chloro-7-fluoro-6-nitroquinazoline is an intermediate in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
Properties of 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE
| Boiling point: | 395℃ |
| Density | 1.649 |
| Flash point: | 193℃ |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| pka | 0.53±0.70(Predicted) |
Safety information for 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE
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