4-Chloro-2-nitroaniline
Synonym(s):1-Amino-4-chloro-2-nitrobenzene
- CAS NO.：89-63-4
- Empirical Formula: C6H5ClN2O2
- Molecular Weight: 172.57
- MDL number: MFCD00007836
- EINECS: 201-925-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is 4-Chloro-2-nitroaniline ?
Chemical properties
bright orange powder
The Uses of 4-Chloro-2-nitroaniline
4-Chloro-2-nitroaniline is used almost exclusively as an intermediate in the synthesis of pigments. The greatest potential for human exposure to 4-chloro-2- nitroaniline is in production and use of pigments made from the compound.
The Uses of 4-Chloro-2-nitroaniline
A nitro-aromatic amine with mutagenicity and carcinogenicity
The Uses of 4-Chloro-2-nitroaniline
4-Chloro-2-nitroaniline is used as pharmaceutical intermediate.
Preparation
4-Chloro-2-nitrobenzenamine of chlorine.
Production Methods
1,4-Dichloro-2-nitrobenzene is aminated at 165 ℃ by using a process similar to that described for 2- nitroaniline.
General Description
Bright orange powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
4-Chloro-2-nitroaniline forms explosive products on reaction with nitric acid. Can react with oxidizing agents.
Hazard
Toxic by ingestion and inhalation.
Fire Hazard
4-Chloro-2-nitroaniline is probably combustible.
Purification Methods
Crystallise the aniline from hot H2O (m 115.8-116o), EtOH, EtOH/H2O or *C6H6, and dry it for 10hours at 60o in vacuo. It has m 115.5-116o after sublimation. [Beilstein 12 H 729, 12 I 355, 12 II 396, 12 III 1649, 12 IV 1669.]
Properties of 4-Chloro-2-nitroaniline
| Melting point: | 117-119 °C(lit.) |
| Boiling point: | 200°C (rough estimate) |
| Density | 1.37 |
| refractive index | 1.6460 (estimate) |
| Flash point: | 191 °C |
| storage temp. | room temp |
| solubility | 0.5g/l (anhydrous substance) |
| pka | pK1: 1.10(+1) (25°C) |
| Colour Index | 37040 |
| form | Crystalline Powder or Chunks |
| color | Orange |
| PH | 7 (0.5g/l, H2O, 20℃) |
| Water Solubility | INSOLUBLE |
| BRN | 512436 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 89-63-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Aniline, 4-chloro-2-nitro-(89-63-4) |
| EPA Substance Registry System | 4-Chloro-2-nitroaniline (89-63-4) |
Safety information for 4-Chloro-2-nitroaniline
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08  Environment GHS09 |
| GHS Hazard Statements |
H373:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P262:Do not get in eyes, on skin, or on clothing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P314:Get medical advice/attention if you feel unwell. |
Computed Descriptors for 4-Chloro-2-nitroaniline
4-Chloro-2-nitroaniline manufacturer
Hemani Global
ASM Organics
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