4-Chloro-2-nitroaniline

Synonym(s):1-Amino-4-chloro-2-nitrobenzene

CAS NO.：89-63-4
Empirical Formula: C6H5ClN2O2
Molecular Weight: 172.57
MDL number: MFCD00007836
EINECS: 201-925-4
SAFETY DATA SHEET (SDS)
Update Date: 2026-06-04 16:00:12

What is 4-Chloro-2-nitroaniline ?

Chemical properties

bright orange powder

The Uses of 4-Chloro-2-nitroaniline

4-Chloro-2-nitroaniline is used almost exclusively as an intermediate in the synthesis of pigments. The greatest potential for human exposure to 4-chloro-2- nitroaniline is in production and use of pigments made from the compound.

The Uses of 4-Chloro-2-nitroaniline

A nitro-aromatic amine with mutagenicity and carcinogenicity

The Uses of 4-Chloro-2-nitroaniline

4-Chloro-2-nitroaniline is used as pharmaceutical intermediate.

Preparation

4-Chloro-2-nitrobenzenamine of chlorine.

Production Methods

1,4-Dichloro-2-nitrobenzene is aminated at 165 ℃ by using a process similar to that described for 2- nitroaniline.

General Description

Bright orange powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Chloro-2-nitroaniline forms explosive products on reaction with nitric acid. Can react with oxidizing agents.

Hazard

Toxic by ingestion and inhalation.

Fire Hazard

4-Chloro-2-nitroaniline is probably combustible.

Purification Methods

Crystallise the aniline from hot H2O (m 115.8-116o), EtOH, EtOH/H2O or *C6H6, and dry it for 10hours at 60o in vacuo. It has m 115.5-116o after sublimation. [Beilstein 12 H 729, 12 I 355, 12 II 396, 12 III 1649, 12 IV 1669.]

Properties of 4-Chloro-2-nitroaniline

Melting point:	117-119 °C(lit.)
Boiling point:	200°C (rough estimate)
Density	1.37
refractive index	1.6460 (estimate)
Flash point:	191 °C
storage temp.	room temp
solubility	0.5g/l (anhydrous substance)
pka	pK1: 1.10(+1) (25°C)
Colour Index	37040
form	Crystalline Powder or Chunks
color	Orange
PH	7 (0.5g/l, H2O, 20℃)
Water Solubility	INSOLUBLE
BRN	512436
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	89-63-4(CAS DataBase Reference)
NIST Chemistry Reference	Aniline, 4-chloro-2-nitro-(89-63-4)
EPA Substance Registry System	4-Chloro-2-nitroaniline (89-63-4)

Safety information for 4-Chloro-2-nitroaniline

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H373:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P262:Do not get in eyes, on skin, or on clothing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P314:Get medical advice/attention if you feel unwell.