5-Chloro-2-nitroaniline

Synonym(s):2-Amino-4-chloro-nitrobenzene

CAS NO.：1635-61-6
Empirical Formula: C6H5ClN2O2
Molecular Weight: 172.57
MDL number: MFCD00007776
EINECS: 216-661-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:12:42

What is 5-Chloro-2-nitroaniline?

Chemical properties

yellow to orange powder

The Uses of 5-Chloro-2-nitroaniline

5-Chloro-2-nitroaniline is a useful synthetic intermediate. It can be used as a reagent to synthesize benzamide derivatives as histone deacetylase inhibitors. It is an intermediate used to synthesize 1-Nitro Febantel a Febantel impurity.

The Uses of 5-Chloro-2-nitroaniline

5-Chloro-2-nitroaniline was used in the synthesis of 5-(4-substituted piperazin-1-yl)-2-nitroanilines and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates.

What are the applications of Application

5-Chloro-2-nitroaniline is 5-Chloro-2-nitroaniline is a useful synthetic intermediate. It can be used as a reagent to synthesize benzamide derivatives as histone deacetylase inhibitors.

What are the applications of Application

5-Chloro-2-nitroaniline was used in the synthesis of 5-(4-substituted piperazin-1-yl)-2-nitroanilines and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates.
The coupling of divinylbenzene cross-linked polystyrene with 5-chloro-2-nitroaniline followed by oxidative decyanation afforded benzophenone.

General Description

The coupling of divinylbenzene cross-linked polystyrene with 5-chloro-2-nitroaniline followed by oxidative decyanation afforded benzophenone.

Properties of 5-Chloro-2-nitroaniline

Melting point:	125-129 °C (dec.)(lit.)
Boiling point:	200°C (rough estimate)
Density	1.5610 (rough estimate)
refractive index	1.5870 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	soluble in Chloroform, Methanol
pka	-1.46±0.25(Predicted)
form	Liquid
color	Clear colorless to light yellow
BRN	2210201
CAS DataBase Reference	1635-61-6(CAS DataBase Reference)

Safety information for 5-Chloro-2-nitroaniline

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H373:Specific target organ toxicity, repeated exposure H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P262:Do not get in eyes, on skin, or on clothing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection.