4-bromo-2,1,3-benzothiadiazole

CAS NO.：22034-13-5
Empirical Formula: C6H3BrN2S
Molecular Weight: 215.07
MDL number: MFCD00614355
EINECS: 1533716-785-6
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-24 18:13:48

What is 4-bromo-2,1,3-benzothiadiazole?

The Uses of 4-bromo-2,1,3-benzothiadiazole

The Sonogashira cross-coupling reaction between 4-bromo-2, 1,3-benzothiadiazole, and the respective para-substituted phenylethynyl derivatives could synthesize the BTDs. In addition, the BTD-Ph is prepared by reacting 4-bromo-2,1,3-benzothiadiazole (Br-BTD)and palladium-MAI catalyst, and the dynamic phenylboronic acid reagent in the starting system or dynamic o-amino pyridine reagent[1-2].

References

[1] Pradhan, Asit Kumar et al. “Effects of donor and acceptor substituents on the photophysics of 4-ethynyl-2,1,3-benzothiadiazole derivatives?.” Physical Chemistry Chemical Physics 42 (2023): 29327–29340.
[2] AMARO DA SILVEIRA NETO B; CORREA J R; OLIVEIRA CARVALHO T; PIMENTA ROCHA CARVALHO P. "Selective cellular markers in selective cellular imaging of organelles such as mitochondria, nucleus and other organelles, are derived from 4-bromo-2,1,3-benzothiadiazole nucleus via homogeneous catalysis of palladium complex" BR102016025541(A2)

Properties of 4-bromo-2,1,3-benzothiadiazole

Melting point:	80 °C
Boiling point:	272.2±13.0 °C(Predicted)
Density	1.859±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	-1.02±0.45(Predicted)

Safety information for 4-bromo-2,1,3-benzothiadiazole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.