4-Amino-2-chloropyridine

CAS NO.：14432-12-3
Empirical Formula: C5H5ClN2
Molecular Weight: 128.56
MDL number: MFCD00060089
EINECS: 238-403-0
SAFETY DATA SHEET (SDS)
Update Date: 2025-04-29 15:35:11

What is 4-Amino-2-chloropyridine?

The Uses of 4-Amino-2-chloropyridine

4-Amino-2-chloropyridine may be used in the preparation of:

3-deazacytosine
7-substituted 1-alky-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acids
1,6-naphthyridines

Definition

ChEBI: 4-Amino-2-chloropyridine is an aminopyridine.

What are the applications of Application

4-Amino-2-chloropyridine is an aminopyridine derivative with potential herbicidal activity. It is used as a drug and pigment intermediate. It is an additive for plant growth regulators.

General Description

4-Amino-2-chloropyridine is a chloroaminoheterocyclic compound. It readily undergoes Suzuki-Miyaura coupling with phenylboronic acid.

Synthesis

4-Amino-2-chloropyridine is also known as 2-chloro-4-aminopyridine and is synthesised as follows:
(1) Using 2-chloropyridine as raw material and chloroform as solvent, 2-chloropyridine oxide is generated under the action of metachloroperbenzoic acid;
(2) 2-chloropyridine oxide is reacted with concentrated nitric acid and concentrated sulphuric acid CID to generate 2-chloro-4-nitro pyridine nitric oxide;
(3) 2-chloro-4-nitro pyridine nitric oxide is reduced to 2-chloro-4-aminopyridine.

Properties of 4-Amino-2-chloropyridine

Melting point:	90-94 °C(lit.)
Boiling point:	153°C 5mm
Density	1.2417 (rough estimate)
refractive index	1.5110 (estimate)
Flash point:	153°C/5mm
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	4.73±0.30(Predicted)
form	Crystalline Powder
color	Light yellow
Water Solubility	Slightly soluble in water.
BRN	108671
CAS DataBase Reference	14432-12-3(CAS DataBase Reference)
NIST Chemistry Reference	4-Amino-2-chloropyridine(14432-12-3)

Safety information for 4-Amino-2-chloropyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.