O-Desmorpholinopropyl Gefitinib
- CAS NO.：184475-71-6
- Empirical Formula: C15H11ClFN3O2
- Molecular Weight: 319.72
- MDL number: MFCD09908046
- EINECS: 1806241-263-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-04 14:24:05
What is O-Desmorpholinopropyl Gefitinib?
Description
O-Desmorpholinopropyl Gefitinib is a metabolite of Gefitinib, a potent inhibitor of tyrosine phosporylation in EGFR. The chemical structure of O-Desmorpholinopropyl Gefitinib consists of a quinazoline-6-ol core with a phenylamino group attached to a chloro-fluoro-phenyl ring, enabling it to interact with multiple biological targets. It is involved in inhibiting enzymes such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).
Chemical properties
Tan Solid
The Uses of O-Desmorpholinopropyl Gefitinib
A metabolite of Gefitinib
The Uses of O-Desmorpholinopropyl Gefitinib
A metabolite of Gefitinib.
Definition
ChEBI: O-Desmorpholinopropyl Gefitinib is a member of quinazolines.
Properties of O-Desmorpholinopropyl Gefitinib
| Melting point: | >260°C (dec.) |
| Boiling point: | 478.8±45.0 °C(Predicted) |
| Density | 1.489±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Very Slightly, Heated) |
| form | Solid |
| pka | 8.18±0.40(Predicted) |
| color | Pale Beige to Beige |
Safety information for O-Desmorpholinopropyl Gefitinib
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for O-Desmorpholinopropyl Gefitinib
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