3-Chloro-4-fluoroaniline
Synonym(s):3-Chloro-4-fluoroaniline;chlorofluoroaniline, CFA
- CAS NO.：367-21-5
- Empirical Formula: C6H5ClFN
- Molecular Weight: 145.56
- MDL number: MFCD00007767
- EINECS: 206-682-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:19:34
What is 3-Chloro-4-fluoroaniline?
Chemical properties
dark purple to black solid
The Uses of 3-Chloro-4-fluoroaniline
4-Fluoro-3-chloroaniline, is an organic Fluorinated building block used for the synthesis of pharmaceutical and biologically active compounds such as, novel 6-Fluorobenzothiazole-substituted pyrazole analogues, having antiinflammatory activity.
General Description
The exposure of workers to 3-chloro-4-fluoroaniline (CFA) was monitored by an HPLC method.
Properties of 3-Chloro-4-fluoroaniline
| Melting point: | 42-44 °C (lit.) |
| Boiling point: | 227-228 °C (lit.) |
| Density | 1,226 g/cm3 |
| vapor pressure | 0.01 hPa (20 °C) |
| refractive index | 1,54-1,542 |
| Flash point: | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | 10g/l |
| form | Crystalline Solid |
| pka | 3.60±0.10(Predicted) |
| color | Beige to brown |
| PH | 7 (10g/l, H2O, 20℃) |
| Water Solubility | 10 g/L (20 ºC) |
| BRN | 1562786 |
| Stability: | Stable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates. May be air-sensitive. |
| CAS DataBase Reference | 367-21-5(CAS DataBase Reference) |
| EPA Substance Registry System | 3-Chloro-4-fluoroaniline (367-21-5) |
Safety information for 3-Chloro-4-fluoroaniline
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H373:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P314:Get medical advice/attention if you feel unwell. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 3-Chloro-4-fluoroaniline
| InChIKey | YSEMCVGMNUUNRK-UHFFFAOYSA-N |
3-Chloro-4-fluoroaniline manufacturer
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