(3R)-(-)-3-Aminopyrrolidine dihydrochloride
- CAS NO.：116183-81-4
- Empirical Formula: C4H12Cl2N2
- Molecular Weight: 159.06
- MDL number: MFCD00070604
- EINECS: 634-214-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-04 16:04:00
What is (3R)-(-)-3-Aminopyrrolidine dihydrochloride?
Chemical properties
(R)-3-Aminopyrrolidine dihydrochloride is an optically active 3-aminopyrrolidine derivative, which can be used as a key intermediate in the synthesis of chiral drugs or pesticides.
The Uses of (3R)-(-)-3-Aminopyrrolidine dihydrochloride
(R)-3-Aminopyrrolidine dihydrochloride is a key intermediate in the synthesis of chiral drugs or pesticides, and it can be used in the synthesis of vinylpyrrolidone-Cephaloridine drugs.
Synthesis
(3R)-(-)-3-Aminopyrrolidine dihydrochloride was prepared by reacting (R)-3-(tert-butoxycarbonyl-amino)-pyrrolidine in methanol with chloroform Sulfone at room temperature for 6-9 hours.
Properties of (3R)-(-)-3-Aminopyrrolidine dihydrochloride
| Melting point: | 283°C (dec.) |
| refractive index | -1.1 ° (C=10, H2O) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | Powder |
| color | White to off-white |
| optical activity | [α]20/D 1.8°, c = 1 in H2O |
| Water Solubility | very faint turbidity |
| Sensitive | Hygroscopic |
| BRN | 5852700 |
| CAS DataBase Reference | 116183-81-4(CAS DataBase Reference) |
Safety information for (3R)-(-)-3-Aminopyrrolidine dihydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for (3R)-(-)-3-Aminopyrrolidine dihydrochloride
| InChIKey | NJPNCMOUEXEGBL-RZFWHQLPSA-N |
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