(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one
- CAS NO.：135911-02-3
- Empirical Formula: C29H30N2O2
- Molecular Weight: 438.56
- MDL number: MFCD00903364
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:48:28
![(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one Structural](https://img.chemicalbook.in/CAS/GIF/135911-02-3.gif)
What is (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one?
The Uses of (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one
RP 67580 is a neurokinin-1 receptor (NK1) antagonist.
What are the applications of Application
RP 67580 is a selective antagonist of the tachykinin NK1 receptor
Biological Activity
Potent and selective tachykinin NK 1 receptor antagonist (K i values are 2.9 nM and > 10 μ M for rat NK 1 , and rat NK 2 and NK 3 receptors respectively). Displays higher affinity at rat and mouse than human receptors. Antinociceptive in vivo , possibly partly via inhibition of calcium channels.
Storage
Store at -20°C
Properties of (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one
| storage temp. | Store at +4°C |
| solubility | Soluble to 100 mM in ethanol and to 50 mM in DMSO |
| form | Powder |
Safety information for (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one
Computed Descriptors for (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one
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