mPEG3-CH2COOH

CAS NO.：16024-60-5
Empirical Formula: C9H18O6
Molecular Weight: 222.24
MDL number: MFCD25959645
SAFETY DATA SHEET (SDS)
Update Date: 2025-10-28 16:00:23

What is mPEG3-CH2COOH?

Description

m-PEG4-CH2COOH is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

The Uses of mPEG3-CH2COOH

3,6,9,12-Tetraoxatridecanoic acid is a useful research chemical.

What are the applications of Application

mPEG3-CH2COOH can be used to synthesise lipid couplers of oligo-(14-amino-3,6,9,12-tetraoxotetracosanoic acid) (ATTAn) as monodisperse analogues of poly(ethylene glycol) (PEG) derivatives for use in liposomal drug delivery systems^[1]. mPEG3-CH2COOH contains terminal carboxylic acids. The terminal carboxylic acid readily reacts with primary and secondary amines under EDC, DCC, HATU or other amide coupling conditions to form stable amide bonds. mPEG modification increases the water solubility of the resulting compounds.

References

[1] STEVEN M. ANSELL. Application of Oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid) Lipid Conjugates as Steric Barrier Molecules in Liposomal Formulations[J]. Bioconjugate Chemistry Bioconjugate, 1999. DOI:10.1021/bc990005p.

Properties of mPEG3-CH2COOH

Boiling point:	338.4±27.0 °C(Predicted)
Density	1.127±0.06 g/cm3(Predicted)
pka	3.39±0.10(Predicted)
form	Liquid
color	Colorless to light yellow

Safety information for mPEG3-CH2COOH

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.