3,6-dibromopyrazin-2-amine

CAS NO.：957230-70-5
Empirical Formula: C4H3Br2N3
Molecular Weight: 252.89
MDL number: MFCD11040377
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-16 09:52:37

What is 3,6-dibromopyrazin-2-amine?

The Uses of 3,6-dibromopyrazin-2-amine

It is used as a pharmaceutical intermediate.

Synthesis

Diphenylphosphoryl azide (488 mg, 1.77 mmol) and triethylamine (180 mg, 1.77 mmol) were added to a solution of the acid (500 mg, 1.77 mmol) in tert-butanol (12 mL). The reaction mixture was stirred at reflux for 18 h and then quenched with water. The volatiles were removed under reduced pressure. The residue was dissolved in 4:1 TFA/DCM (5 mL) and stirred at rt for 1 h. The volatiles were removed under reduced pressure. The residue was dissolved in DCM and washed with 1N aq. NaOH. The combined organic extracts were dried (Na2SO4), filtered and concentrated. The crude residue was purified by SiO2 chromatography eluting with an EtOAc/hexane gradient to afford 3,6-dibromopyrazin-2-amine 120 mg (27%) of bromoanisol as a colorless oil. MS m/z (ES): 253 (M+H)+.
3,6-dibromopyrazin-2-amine synthesis

Properties of 3,6-dibromopyrazin-2-amine

Boiling point:	314℃
Density	2.287
Flash point:	144℃
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	0.05±0.10(Predicted)
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C4H3Br2N3/c5-2-1-8-3(6)4(7)9-2/h1H,(H2,7,9)

Safety information for 3,6-dibromopyrazin-2-amine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.