3,4-Dichloronitrobenzene

Chemical properties

colourless to yellow crystals or beige powder

The Uses of 3,4-Dichloronitrobenzene

1,2-Dichloro-4-nitrobenzene is an intermediate in the synthesis of agrochemicals. Studies have been conducted to use 1,2-Dichloro-4-nitrobenzene as an organic intermediate for the synthetic preparati on of ciprofloxacin (C482500).

The Uses of 3,4-Dichloronitrobenzene

1,2-Dichloro-4-nitrobenzene is an intermediate in the synthesis of agrochemicals. Studies have been conducted to use 1,2-Dichloro-4-nitrobenzene as an organic intermediate for the synthetic preparation of ciprofloxacin (C482500).

What are the applications of Application

1,2-Dichloro-4-nitrobenzene is a useful halogenated nitro compound for proteomics research

Production Methods

Nitration of 1,2-dichlorobenzene with mixed acid at 35 – 60 ℃ results in a mixture of 3-nitro (10 %) and 4-nitro (90 %) isomers, which are separated by crystallization. A more expensive process (two stages from chlorobenzene) is based on chlorination of molten 4-chloronitrobenzene (90 – 100 ℃) by a process similar to that used for 3- chloronitrobenzene production. Chlorination has the advantage of giving a pure product, but it cannot be used if the isomeric 1,2-dichloro-3-nitrobenzene is also required.

Synthesis Reference(s)

The Journal of Organic Chemistry, 42, p. 3494, 1977 DOI: 10.1021/jo00442a009

General Description

Colorless crystals or light beige solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Can react vigorously with oxidizing materials.

Fire Hazard

3,4-Dichloronitrobenzene is combustible.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise it from absolute EtOH. [Beilstein 5 IV 726.]