3-NITRO-2-PYRIDINESULFENYL CHLORIDE
- CAS NO.：68206-45-1
- Empirical Formula: C5H3ClN2O2S
- Molecular Weight: 190.61
- MDL number: MFCD00274609
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:30:30
What is 3-NITRO-2-PYRIDINESULFENYL CHLORIDE?
The Uses of 3-NITRO-2-PYRIDINESULFENYL CHLORIDE
3-Nitro-2-pyridinesulfenyl chloride (NpysCl) was employed as the starting material for the synthesis of N-, O- and S-Npys-protected amino acid.
What are the applications of Application
3-Nitro-2-pyridinesulfenyl chloride is used to initiate N-, O- and S-Npys-protected amino acid synthesis
General Description
The 3-nitro-2-pyridinesulphenyl (Npys) moiety is useful as a protecting-activating group for cysteine, particularly in the synthesis of cyclic and unsymmetrical disulfides. The stability of NpysCl was studied in various solvents.
Purification Methods
The chloride crystallises as yellow needles from CH2Cl2. When pure, it is stable for several weeks at room temperature, and no decomposition was observed after 6 months at <0o. It is moisture sensitive. UV (MeCN) has at 231nm max ( 12,988), 264nm ( 5,784) and 372nm ( 3,117). [NMR and UV: Matsuda & Aiba Chem Lett 951 1978, Wagner et al. Chem Ber 75 935 1942.]
Properties of 3-NITRO-2-PYRIDINESULFENYL CHLORIDE
| Melting point: | 205 °C (dec.) (lit.) |
| Boiling point: | 376.8±27.0 °C(Predicted) |
| Density | 1.58±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | dichloromethane: soluble(lit.) |
| pka | -3.72±0.29(Predicted) |
Safety information for 3-NITRO-2-PYRIDINESULFENYL CHLORIDE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-NITRO-2-PYRIDINESULFENYL CHLORIDE
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