3-Fluoropyridine
- CAS NO.:372-47-4
- Empirical Formula: C5H4FN
- Molecular Weight: 97.09
- MDL number: MFCD00006374
- EINECS: 206-755-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is 3-Fluoropyridine?
Chemical properties
clear, colorless to yellow liquid.
The Uses of 3-Fluoropyridine
3-Fluoropyridine was used in the synthesis of 3-halopyridin-4-yl-boronic acids and esters.
Preparation
A combination of CsF and HF provides a very reactive fluoride source and has shown faint promise with 3-chloropyridine giving 3-fluoropyridine in a very low yield.
General Description
3-Fluoropyridine is oxidized to corresponding N-oxides, which on treatment with hot acetic anhydride and hydrolysis yields 3-halo-2-pyridones. Microwave spectrum of 3-fluoropyridine has been investigated in the frequency range of 8-18GHz at dry ice temperature. Deprotonation of 3-fluoropyridine with Bu3MgLi in THF at -10°C has been studied.
Properties of 3-Fluoropyridine
| Melting point: | 251-254°C (dec.) |
| Boiling point: | 107-108 °C (lit.) |
| Density | 1.13 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 56 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| form | Liquid |
| pka | pK1:2.97(+1) (25°C) |
| Specific Gravity | 1.130 |
| color | Clear yellow |
| BRN | 105702 |
| CAS DataBase Reference | 372-47-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-F-pyridine(372-47-4) |
Safety information for 3-Fluoropyridine
| Signal word | Danger |
| Pictogram(s) |
![]() Flame Flammables GHS02 ![]() Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Fluoropyridine
| InChIKey | CELKOWQJPVJKIL-UHFFFAOYSA-N |
3-Fluoropyridine manufacturer
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