3-Aminoacetophenone

Chemical properties

3-Aminoacetophenone is yellow to light brown crystalline powder

The Uses of 3-Aminoacetophenone

3'-Aminoacetophenone has potential anti-bacterial properties in addition to being used in the synthesis of selective antagonists at human A2B adenosine receptors. As well, it is used in the synthesis of HIV-1 Integrase Inhibitors.

The Uses of 3-Aminoacetophenone

3′-Aminoacetophenone (3-Acetylaniline) was used as reagent during the asymmetric total synthesis of pactamycin. It was used as starting reagent during the synthesis of curcumin mimics with substituted sulfonyl group.

Definition

ChEBI: 3'-Aminoacetophenone is an aromatic ketone.

Synthesis Reference(s)

Synthetic Communications, 26, p. 973, 1996 DOI: 10.1080/00397919608003701

General Description

3′-Aminoacetophenone acts as bifunctional coupling reagent during the synthesis of pyrimidines.

Safety Profile

Moderately toxic by ingestion. Mddly toxic by skin contact. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NO,. See also AROMATIC AMINES.

Purification Methods

Recrystallise it from EtOH or aqueous EtOH (m 99.5o). The thiosemicarbazone has m 202-204o (from EtOH). [Beilstein 14 H 45, 14 IV 96.]