OSI-420
- CAS NO.：183320-51-6
- Empirical Formula: C21H22ClN3O4
- Molecular Weight: 415.87
- MDL number: MFCD22420811
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-11 19:39:08
What is OSI-420?
The Uses of OSI-420
OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.
The Uses of OSI-420
OSI 420 can be used in biological study of effects of cytochrome P 450 3A on pharmacokinetic interaction between erlotinib and docetaxel in rats.
Properties of OSI-420
| storage temp. | Store at -20°C |
| solubility | DMSO : 50 mg/mL (120.23 mM; Need ultrasonic) |
| form | Powder |
| color | White to off-white |
Safety information for OSI-420
Computed Descriptors for OSI-420
New Products
6-Hydroxy-2,4-Diaminopyrimidine 2,6-Dipicolic Acid 3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 4-Fluorophenylglycine 1-N-Boc-3-(aminoethyl)azetidine Dimedone 1-Boc-3-(cyanomethyl)azetidine N-BOC-piperidine-4-carboxylic acid 2-Amino-5-Bromo Pyridine 2-Amino-5-Iodopyridine 2,5-Dibromopyridine METHANOL-D1(OD) 3-BROMO PYRIDINE-D4 2-BROMOACETYL BROMIDE-D2 DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3 5-Acetylsalicylamide 1-(3-Chlorophenyl)-4-(3-Chloropropyl) piperazine hydrochloride 4-(Methyl amino)-3-Nitro benzoic acid 3,4,5-Trimethoxy benzoic acidRelated products of tetrahydrofuran
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