(2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid
Synonym(s):(2R,4R)-N-Boc-4-hydroxy-2-pyrrolidinecarboxylic acid
- CAS NO.：135042-12-5
- Empirical Formula: C10H17NO5
- Molecular Weight: 231.25
- MDL number: MFCD02094407
- EINECS: 621-971-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-08-25 20:17:46
What is (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid?
Chemical properties
White solid
The Uses of (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid
N-Boc-cis-4-hydroxy-D-proline can be used:
- As a starting material in the synthesis of DNA mimicking pyrrolidine peptide nucleic acid (PNA) analog.
- In the synthesis of biologically important macrocyclic dilactones.
- As an intermediate in the synthesis of histamine H3?receptor antagonists.
Properties of (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid
| Melting point: | 146-151 °C |
| Boiling point: | 390.9±42.0 °C(Predicted) |
| alpha | +48～+52°(c=0.67,MeOH,24℃) |
| Density | 1.312 |
| storage temp. | 2-8°C |
| pka | 3.80±0.40(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| optical activity | [α]22/D +50.0°, c = 1 in methanol |
Safety information for (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid
| InChIKey | BENKAPCDIOILGV-RNFRBKRXSA-N |
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