2,6-DIAMINOPIMELIC ACID

Chemical properties

white to beige powder and/or chunks

The Uses of 2,6-DIAMINOPIMELIC ACID

2,6-Diaminopimelic acid is used as a constituent of proteoglycans. It is used as a component of bacterial cell wall.

The Uses of 2,6-DIAMINOPIMELIC ACID

Mixture of LL-, DD- and meso-isomers

The Uses of 2,6-DIAMINOPIMELIC ACID

2,6-Diaminopimelic acid (2,6-DAP) can be used as a building block in the synthesis of tripeptides , and γ-glutamyldiaminopimelic acid derivatives.

Definition

ChEBI: The amino dicarboxylic acid that is heptanedioic acid with amino aubstituents at C-2 and C-6.

General Description

2,6-Diaminopimelic acid is produced in bacteria and is a component of cell wall. It is also synthesized by higher plants.

Biochem/physiol Actions

2,6-Diaminopimelic acid is essential for microbial metabolism and is a potential marker for quantification of microbial proteins. It is a sensitive and reliable marker and is majorly quantified using gradient high-performance liquid chromatography (HPLC).

Purification Methods

Crystallise the acid from H2O or aqueous EtOH. Also purify it by dissolving it in hot H2O and adding 5volumes of EtOH, filter after 12hours at -10o. The acid has been recrystallised from 35% aqueous EtOH [Wade et al. J Am Chem Soc 79 648, 651 1957]. [Beilstein 4 IV 3081.]