2',4'-Dihydroxy-2-phenylacetophenone
Synonym(s):2′,4′-Dihydroxy-2-phenylacetophenone
- CAS NO.：3669-41-8
- Empirical Formula: C14H12O3
- Molecular Weight: 228.24
- MDL number: MFCD00043754
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 23:34:18
What is 2',4'-Dihydroxy-2-phenylacetophenone?
Chemical properties
off-white crystalline powder
The Uses of 2',4'-Dihydroxy-2-phenylacetophenone
1-(2,4-Dihydroxyphenyl)-2-phenylethanone is used in preparation of substituted pyrazoles, pyrimidines, triazoles and related heterocycles as c-MYC targeting agents for treatment of cancer and other proliferative diseases.
Preparation
Preparation by Friedel–Crafts acylation of resorcinol with phenylacetyl chloride in the presence of aluminium chloride,
? in methylene chloride (85%) ;
? in nitrobenzene at 70–80° for 15 min (<80%), at r.t. for 24 h (63%) or for 2 days (60%);
? in ethyl ether at r.t. for 24 h (43%).
Properties of 2',4'-Dihydroxy-2-phenylacetophenone
| Melting point: | 112-116 °C(lit.) |
| Boiling point: | 225°C/10mmHg(lit.) |
| Density | 1.278±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 7.74±0.35(Predicted) |
| color | White to Light yellow to Light orange |
| CAS DataBase Reference | 3669-41-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 2,4-Dihydroxyphenylbenzyl ketone(3669-41-8) |
Safety information for 2',4'-Dihydroxy-2-phenylacetophenone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2',4'-Dihydroxy-2-phenylacetophenone
New Products
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