2-HYDROXYACETOPHENONE

CAS NO.：582-24-1
Empirical Formula: C8H8O2
Molecular Weight: 136.15
MDL number: MFCD00041829
EINECS: 209-480-8
SAFETY DATA SHEET (SDS)
Update Date: 2025-04-17 18:22:24

What is 2-HYDROXYACETOPHENONE?

Chemical properties

slightly yellow to orange powder

The Uses of 2-HYDROXYACETOPHENONE

2-Hydroxyacetophenone can be used to produce 2-hydroxy-1-phenyl-ethanone-(1)-oxime by heating. It is used as pharmaceutical intermediate.

The Uses of 2-HYDROXYACETOPHENONE

2-Hydroxyacetophenone can be used as a starting material for the synthesis of:

Enantioselective 1R-phenyl-1,2-ethanediol in the presence of a rhodium(III) catalyst by asymmetric transfer hydrogenation.
Copper(II) complexes of 2-hydroxyacetophenone N-substituted thiosemicarbazones.
Chromium, molybdenum, and ruthenium complexes of 2-hydroxyacetophenone Schiff bases.
2-Hydroxyacetophenone-aroyl hydrazone derivatives for inhibition of copper corrosion in nitric acid.

Definition

ChEBI: 2-hydroxyacetophenone is a monohydroxyacetophenone that is acetophenone in which one of the methyl hydrogens has been replaced by a hydroxy group. It is a primary alcohol, a primary alpha-hydroxy ketone and a monohydroxyacetophenone.

Properties of 2-HYDROXYACETOPHENONE

Melting point:	86-89 °C (lit.)
Boiling point:	126 °C / 12mmHg
Density	1.0963
refractive index	1.5470 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	13.09±0.10(Predicted)
form	Powder
color	Slightly yellow to orange
Water Solubility	Soluble in water, ether, ethanol, chloroform.
Sensitive	Air & Moisture Sensitive
CAS DataBase Reference	582-24-1(CAS DataBase Reference)
NIST Chemistry Reference	«alpha»-Hydroxyacetophenone(582-24-1)
EPA Substance Registry System	Ethanone, 2-hydroxy-1-phenyl- (582-24-1)

Safety information for 2-HYDROXYACETOPHENONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.