2,4-Difluorobenzenesulfonyl chloride
- CAS NO.：13918-92-8
- Empirical Formula: C6H3ClF2O2S
- Molecular Weight: 212.6
- MDL number: MFCD00042481
- EINECS: 629-141-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:53:02
What is 2,4-Difluorobenzenesulfonyl chloride?
Chemical properties
clear colorless to light yellow liquid
The Uses of 2,4-Difluorobenzenesulfonyl chloride
2,4-Difluorobenzenesulfonyl chloride may be used in the preparation of 2,4-difluoro-N,N-dimethylbenzenesulfonamide, a precursor for poly(aryl ether sulfonamide)s.
It may be used in the preparation of the following benzenesulfonamide quinoline derivatives with potent anti-HIV-1 (human immunodeficiency virus type 1) activity:
- 2,4-difluoro-N-methyl-N-(quinolin-8-yl)benzenesulfonamide
- N-ethyl-2,4-difluoro-N-(quinolin-8-yl)benzenesulfonamide
- 2,4-difluoro-N-(quinolin-8-yl)benzenesulfonamide
General Description
2,4-Difluorobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative.
Properties of 2,4-Difluorobenzenesulfonyl chloride
| Boiling point: | 101-102 °C (1 mmHg) |
| Density | 1.581 g/mL at 25 °C(lit.) |
| refractive index | 1.5187 |
| Flash point: | >110°C |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | Liquid |
| color | Clear colorless to light yellow |
| Sensitive | Moisture Sensitive |
| BRN | 2970373 |
| CAS DataBase Reference | 13918-92-8(CAS DataBase Reference) |
Safety information for 2,4-Difluorobenzenesulfonyl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2,4-Difluorobenzenesulfonyl chloride
| InChIKey | FJSAJUXIHJIAMD-UHFFFAOYSA-N |
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