2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino[3,2,1-j,k]carbazole mesylate

CAS NO.：60762-57-4
Empirical Formula: C15H18N2
Molecular Weight: 226.32
MDL number: MFCD00407230
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:48:27

What is 2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino[3,2,1-j,k]carbazole mesylate?

Description

Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC₅₀s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively). It is selective for MAO-A over MAO-B (K_is = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC₅₀ value of 7.7 μM independent of MAO-A activity.

The Uses of 2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino[3,2,1-j,k]carbazole mesylate

Antidepressive;Monoamine oxidase inhibitor

What are the applications of Application

Pirlindole mesylate is an inhibitor of monoamine oxidase type A

Biological Activity

A highly selective reversible inhibitor of monoamine oxidase type A.

Properties of 2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino[3,2,1-j,k]carbazole mesylate

storage temp.	Store at RT
solubility	DMF: 1 mg/ml; DMSO: 5 mg/ml
form	A crystalline solid
color	Off-white to light yellow

Safety information for 2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino[3,2,1-j,k]carbazole mesylate

Computed Descriptors for 2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino[3,2,1-j,k]carbazole mesylate

New Products

2-Amino-5-bromo-4-(trifluoromethyl)pyridine Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde β-Bromostyrene Ethyl 3-phenylpropanoate Phenethyl cinnamate Dipropyl disulfide N-Vinylformamide 4 pentyn 1 ol Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide

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1H-Pyrazino(3,2,1-jk)carbazole, 2,3,3a,4,5,6-hexahydro-8-methyl-3-prop yl-, hydrochloride