2,2-DIFLUOROACETOPHENONE
Synonym(s):α,α-Difluoroacetophenone;2,2-Difluoro-1-phenylethanone;Difluoromethyl phenyl ketone
- CAS NO.：395-01-7
- Empirical Formula: C8H6F2O
- Molecular Weight: 156.13
- MDL number: MFCD06246879
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:14:26
What is 2,2-DIFLUOROACETOPHENONE?
The Uses of 2,2-DIFLUOROACETOPHENONE
2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.
Synthesis Reference(s)
Tetrahedron, 52, p. 15, 1996 DOI: 10.1016/0040-4020(95)00884-B
Properties of 2,2-DIFLUOROACETOPHENONE
| Melting point: | 48-50°C |
| Boiling point: | 53-54°C/12mm |
| Density | 1.180±0.06 g/mL |
| refractive index | 1.4955 |
| Flash point: | 53-54°C/12mm |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | liquid |
| Water Solubility | Immiscible with water. |
| CAS DataBase Reference | 395-01-7 |
Safety information for 2,2-DIFLUOROACETOPHENONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 2,2-DIFLUOROACETOPHENONE
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
You may like
-
2,2-Difluoroacetophenone CAS 395-01-7View Details
395-01-7 -
1122-58-3 99%View Details
1122-58-3 -
5-Methoxy-2-Mercapto Benzimidazole 99%View Details
37052-78-1 -
15128-52-6 99%View Details
15128-52-6 -
2-Chlorotrityl Chloride 99%View Details
42074-68-0 -
5-Bromo-2-chlorobenzoic acid 21739-92-4 99%View Details
21739-92-4 -
106-40-1 99%View Details
106-40-1 -
15128-52-6 1,2,3,9-Tetrahydro-4(H)-carbazol-4-one 99%View Details
15128-52-6
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.