2,2-Difluoroacetophenone
Synonym(s):α,α-Difluoroacetophenone;2,2-Difluoro-1-phenylethanone;Difluoromethyl phenyl ketone
- CAS NO.：395-01-7
- Empirical Formula: C8H6F2O
- Molecular Weight: 156.13
- MDL number: MFCD06246879
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-10-27 18:05:18
What is 2,2-Difluoroacetophenone?
The Uses of 2,2-Difluoroacetophenone
2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.
Synthesis Reference(s)
Tetrahedron, 52, p. 15, 1996 DOI: 10.1016/0040-4020(95)00884-B
Properties of 2,2-Difluoroacetophenone
| Melting point: | 48-50°C |
| Boiling point: | 53-54°C/12mm |
| Density | 1.180±0.06 g/mL |
| refractive index | 1.4955 |
| Flash point: | 53-54°C/12mm |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | liquid |
| Water Solubility | Immiscible with water. |
| CAS DataBase Reference | 395-01-7 |
Safety information for 2,2-Difluoroacetophenone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 2,2-Difluoroacetophenone
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