2-Chloro-2,2-difluoroacetophenone

Synonym(s):α-Chloro-α,α-difluoroacetophenone;2-Chloro-2,2-difluoro-1-phenylethanone;Chlorodifluoromethyl phenyl ketone

CAS NO.：384-67-8
Empirical Formula: C8H5ClF2O
Molecular Weight: 190.57
MDL number: MFCD00042123
EINECS: 621-031-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:54:54

2-Chloro-2,2-difluoroacetophenone Structural

What is 2-Chloro-2,2-difluoroacetophenone?

Description

Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally diverse phenol derivatives and N-heterocyclic compounds.

The Uses of 2-Chloro-2,2-difluoroacetophenone

2-Chloro-2,2-difluoroacetophenone can be used:

As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.

General Description

2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem?-difluoromethene derived compounds.

Properties of 2-Chloro-2,2-difluoroacetophenone

Melting point:	102-103 °C
Boiling point:	94-96 °C35 mm Hg(lit.)
Density	1.293 g/mL at 25 °C(lit.)
refractive index	n20/D 1.497(lit.)
Flash point:	163 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Difficult to mix.
color	Clear, colourless
BRN	2251448
CAS DataBase Reference	384-67-8(CAS DataBase Reference)

Safety information for 2-Chloro-2,2-difluoroacetophenone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.