2-PYRAZINECARBONYL CHLORIDE
- CAS NO.：19847-10-0
- Empirical Formula: C5H3ClN2O
- Molecular Weight: 142.54
- MDL number: MFCD00792886
- EINECS: 243-367-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 2-PYRAZINECARBONYL CHLORIDE?
The Uses of 2-PYRAZINECARBONYL CHLORIDE
2-Pyrazinecarbonyl Chloride is an intermediate used in the synthesis of (S)-N-[1-(3-Hydroxy-3-methylbutanamido)-1-oxo-3-phenylpropan-2yl]pyrazine-2-carboxamide (H805105), which is an impurity of bortezomib (B675700), which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
Properties of 2-PYRAZINECARBONYL CHLORIDE
| Melting point: | 41°C |
| Boiling point: | 214.5±20.0 °C(Predicted) |
| Density | 1.393±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | -2.50±0.10(Predicted) |
| Water Solubility | Reacts with water. |
| Sensitive | Moisture Sensitive |
| CAS DataBase Reference | 19847-10-0(CAS DataBase Reference) |
Safety information for 2-PYRAZINECARBONYL CHLORIDE
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2-PYRAZINECARBONYL CHLORIDE
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