2’-O-Methyl-rA(N-Bz)phosphoramidite
Synonym(s):DMT-2′-O-Me-rA(bz) amidite;N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-adenosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
- CAS NO.：110782-31-5
- Empirical Formula: C48H54N7O8P
- Molecular Weight: 887.96
- MDL number: MFCD00792622
- EINECS: 200-100-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-08-06 14:26:04
What is 2’-O-Methyl-rA(N-Bz)phosphoramidite?
Chemical properties
White or off-white power
The Uses of 2’-O-Methyl-rA(N-Bz)phosphoramidite
(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a nucleotide used in the synthesis of native-like crosslinked duplex RNA.
General Description
Proligo′s 2′O-Methyl RNA monomers are compatible with fast deprotectionschemes that are based on the application of aliphatic amines, such asmethylamine. The adenosine and guanosine monomers are protected bythe standard benzoyl (bz) and isobutyryl (ib) groups.2′O-Methyl RNA is a nucleic acid analog that is characterized by theexceptional hybridization properties that it imparts with complimentary DNA or RNA, as well as increased stability against enzymatic degradationcompared to natural nucleic acids.The unique combination of properties of 2′O-Methyl RNA had foundwidespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules
Properties of 2’-O-Methyl-rA(N-Bz)phosphoramidite
| Melting point: | 93-95°C |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Acetonitrile (Sparingly), DMSO (Slightly), Methanol (Slightly) |
| form | powder |
| pka | 7.87±0.43(Predicted) |
| color | white to off-white |
Safety information for 2’-O-Methyl-rA(N-Bz)phosphoramidite
Computed Descriptors for 2’-O-Methyl-rA(N-Bz)phosphoramidite
| InChIKey | AZCGOTUYEPXHMJ-DCATYJMPNA-N |
New Products
5-bromo-4-fluoro-2-nitrobenzaldehyde (R)-(-)-2-Amino-1-propanol Cyclobutanone Fmoc-OSu 1-(2-Chloroethyl)pyrrolidine Hydrochloride 2-Amino-2-(4-methylphenyl)acetic acid β-Bromostyrene Ethyl 3-phenylpropanoate Phenethyl cinnamate Dipropyl disulfide 4 pentyn 1 ol N-Vinylformamide Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
You may like
-
5'-ODMT-2'-OMe-N-Bz Adenosine-3'-OCEPA 110782-31-5 98%View Details
110782-31-5 -
Dmt-2'-o-me-ra(bz) amidite 95% CAS 110782-31-5View Details
110782-31-5 -
DMT-2′O-Methyl-rA(bz) Phosphoramidite CAS 110782-31-5View Details
110782-31-5 -
DMT-2′O-Methyl-rA(bz) Phosphoramidite CAS 110782-31-5View Details
110782-31-5 -
DMT-2′O-Methyl-rA(bz) Phosphoramidite CAS 110782-31-5View Details
110782-31-5 -
DMT-2′O-Methyl-rA(bz) Phosphoramidite CAS 110782-31-5View Details
110782-31-5 -
N6-Benzoyl-5' -O-DMT-2' -O-methyladenosine-3' -O[O-(2-cya noethyl)-N, N'-di isopropyl phosphora mid ite, Me-rABz Phosphoramidite, D70` 98%View Details
110782-31-5 -
7250-67-1 1-(2-Chloroethyl)pyrrolidine Hydrochloride 98+View Details
7250-67-1