2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
Synonym(s):N,N-Bis(trifluoromethylsulfonyl)-5-chloro-2-pyridylamine;2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine;Comins’ Reagent
- CAS NO.：145100-51-2
- Empirical Formula: C7H3ClF6N2O4S2
- Molecular Weight: 392.68
- MDL number: MFCD00191833
- EINECS: 629-110-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 17:24:25
![2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Structural](https://img.chemicalbook.in/CAS/GIF/145100-51-2.gif)
What is 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE?
Chemical properties
White to pale yellow crystalline solid
The Uses of 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine provides good yields of vinyl triflates from the corresponding ketone enolates or dienolates. It is used in the total synthesis of (-)-porantheridine and the trans decahydroquinoline alkaloid (+)-219A. It is also used as a reactant for Suzuki-Miyaura cross coupling, synthesis of nicotinic acetylcholine receptor-selective ligands, enantioselective desymmetrizing palladium catalyzed carbonylation reactions, synthesis of high affinity niacin receptor GPR109A agonists and in preparation of heteroaromatics.
The Uses of 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
Reactant for:
Suzuki-Miyaura cross coupling
Synthesis of nicotinic acetylcholine receptor-selective ligands
Enantioselective desymmetrizing palladium catalyzed carbonylation reactions
Synthesis of high affinity niacin receptor GPR109A agonists
Preparation of heteroaromatics
Properties of 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
| Melting point: | 45-47 °C(lit.) |
| Boiling point: | 77-90°C/0.2mmHg |
| Density | 1.892±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Benzene (Slightly) |
| form | Solid |
| pka | -7.71±0.10(Predicted) |
| color | yellow |
| Water Solubility | Reacts with water. |
| Sensitive | Moisture Sensitive |
| BRN | 5833971 |
| Stability: | Moisture Sensitive, Unstable in DMSO Solution |
| CAS DataBase Reference | 145100-51-2(CAS DataBase Reference) |
Safety information for 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
| InChIKey | TUFGVZMNGTYAQD-UHFFFAOYSA-N |
New Products
9-Mesityl-10-methylacridinium perchlorate Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde 4 pentyn 1 ol N-Vinylformamide Phenethyl cinnamate Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Ethyl 3-phenylpropanoate β-Bromostyrene Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 Methyl trans-4-Aminocyclohexanecarboxylate Hydrochloride N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. 4-Nitrobenzotrifluoride 2-Pentyn-1-oL N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
![2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE](https://img.chemicalbook.in/CAS/GIF/145100-50-1.gif)
You may like
-
![2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine CAS 145100-51-2](https://img.chemicalbook.in//Content/image/CP5.jpg)
2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine CAS 145100-51-2View Details
145100-51-2 -
2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent] CAS 145100-51-2View Details
145100-51-2 -
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide) CAS 145100-51-2View Details
145100-51-2 -
Fmoc-OSu 98+View Details
82911-69-1 -
1191-95-3 Cyclobutanone 98+View Details
1191-95-3 -
213382-45-7 98+View Details
213382-45-7 -
Fmoc-OSu 98+View Details
82911-69-1 -
(R)-(-)-2-Amino-1-propanol 35320-23-1 98+View Details
35320-23-1
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.