2-Naphthalenesulfonyl chloride
- CAS NO.：93-11-8
- Empirical Formula: C10H7ClO2S
- Molecular Weight: 226.68
- MDL number: MFCD00004087
- EINECS: 202-219-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:17:25
What is 2-Naphthalenesulfonyl chloride?
Chemical properties
LIGHT YELLOW TO BEIGE POWDER
The Uses of 2-Naphthalenesulfonyl chloride
2-Naphthalenesulfonyl chloride was employed as capping reagent for primary amine to convert histamine to a selective histamine H3-receptor antagonist. It was used for pre-column derivatization during the high-performance liquid chromatographic assay of neomycin sulfate.
Flammability and Explosibility
Not classified
Purification Methods
Distil the chloride in a vacuum and/or recrystallise it (twice) from *benzene/pet ether (1:1 v/v). Purify it as the 1-sulfonyl chloride above. [Fierz-Davaid & Weissenbach Helv Chim Acta 3 2312 1920.] The sulfonamide has m 217o (from EtOH). [Beilstein 11 III 399, 11 IV 529.]
Properties of 2-Naphthalenesulfonyl chloride
| Melting point: | 74-76 °C (lit.) |
| Boiling point: | 147.7 °C/0.6 mmHg (lit.) |
| Density | 1.3661 (estimate) |
| vapor pressure | 0.004Pa at 25℃ |
| Flash point: | 200-202°C/13mm |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Toluene |
| form | Powder |
| color | Light yellow to beige |
| Water Solubility | insoluble |
| Sensitive | Moisture Sensitive |
| BRN | 641898 |
| CAS DataBase Reference | 93-11-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Naphthalenesulfonyl chloride(93-11-8) |
| EPA Substance Registry System | 2-Naphthalenesulfonyl chloride (93-11-8) |
Safety information for 2-Naphthalenesulfonyl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H290:Corrosive to Metals H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P234:Keep only in original container. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Naphthalenesulfonyl chloride
| InChIKey | OPECTNGATDYLSS-UHFFFAOYSA-N |
2-Naphthalenesulfonyl chloride manufacturer
PRODEV PHARMA (OPC) PRIVATE LIMITED
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Phone:+919849892844
Whatsapp: +91-9849892844
product: Naphthalene-2-sulfonyl chloride 98%
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